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Scientists create synthetic 'SpudCell' that feeds, grows and reproduces

scienceJul 1, 202615237

A University of Minnesota team led by synthetic biologist Kate Adamala announced a manmade cell, nicknamed SpudCell for its potato-like appearance, that was assembled from chemical building blocks and can feed, grow, reproduce and compete for food. Adamala said she is hesitant to call SpudCell fully alive because life is not binary; other experts called the achievement dazzling and noted the cell was constructed, not born. The researchers posted a 190-page account of the work online and the study is under review for publication in a scientific journal. Adamala and Stanford synthetic biologist Drew Endy are organizing a community and a nonprofit to develop SpudCells further rather than patenting the design; Endy estimated the effort could spend hundreds of millions of dollars over the next decade and attract hundreds of scientists. The team says synthetic cells like SpudCell could help answer basic questions about minimal gene sets and might eventually be engineered to make novel proteins, medicines, or to capture carbon dioxide, or produce chemicals such as rocket fuel. The paper follows decades of efforts to define minimal cellular functions, including work led by John Glass that reduced a microbe to 525 essential genes while leaving many gene functions unexplained, underscoring why a bottom-up synthetic approach could reveal new biology.

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