FDA approves daraxonrasib for advanced pancreatic cancer

scienceAug 26, 202626465

The Food and Drug Administration approved daraxonrasib, sold as Rasonque by Revolution Medicines, Wednesday for advanced pancreatic cancer, granting expedited review and clearing the first pill that directly targets mutated RAS proteins that drive more than 90 percent of pancreatic tumors. In a company-funded randomized trial of 500 patients whose metastatic disease had stopped responding to prior treatment, patients receiving daraxonrasib lived a median 13.2 months versus 6.7 months for those given chemotherapy, with side effects that included skin rash, mouth sores, diarrhea and other digestive issues. Revolution Medicines set the list cost for a one-month supply at about $39,800. Regulators approved the drug more than six months ahead of their target date, after the FDA had allowed expanded access earlier this year following public attention including former Sen. Ben Sasse describing symptom improvement on television. Fred Hutch Cancer Center oncologist Dr. Andrew Coveler called the approval a significant improvement rather than a cure, and Dr. Pashtoon Kasi of City of Hope said the drug could open doors for other companies pursuing RAS-targeted therapies. U.S. incidence and mortality context cited by the FDA noted roughly 67,000 new U.S. pancreatic cancer diagnoses and more than 52,000 deaths expected this year, underscoring why clinicians see the approval as a major development for a cancer that is hard to detect before it spreads. The agency and oncologists said the approval is likely to accelerate development and testing of additional RAS-directed drugs across cancers.

🌈Dr. Frizzle

@swilua.bsky.social

one of my dear friends died this year from pancreatic cancer the world is less without him I look forward to no one else having to mourn someone gone so fast and too soon I’m glad this gets us closer

1014h ago

KMG3

My best friend’s mom, who I’ve known my whole life (our parents were friends and neighbors) is dying from it now and it’s breaking my heart. She lived a quiet life of service, and like so many others, doesn’t deserve to go out like this.

NLCBIO2

My uncle passed from it in May. My husband has had several clients in the last two years. It's truly awful.

Jami2

I wish this had come in time to help my friend who is quitting chemo and entering hospice, but it's going to help so many people!

public health guy

@publichealthguy1.bsky.social

just thinking about that new, amazing pancreatic cancer drug in the context of who gets to have access to it and who doesn't.

723h ago

Quoting this

Wanda Monroe3

The first thing I thought about is how much Merck made from Keytruda. I think the figure was $163 billion since it went on the market. Rounded, it's $25,000 every 6 weeks for treatment.

Guardian US

@us.theguardian.com

FDA officials approve first-of-a-kind pill called daraxonrasib to fight one of the deadliest types of cancer

394h ago

Thorne 🌸

@ens0.me

there's also a lot of hope this will help with some other cancers too! daraxonrasib blocks a method a lot of malignancies use to grow, which won't help with all cancers, but it's by no means limited to pancreatic cancer that's just historically such a scary one

336h ago

River_Tam

@rivertam.bsky.social

Regional stage pancreatic cancer 5 year survival rate is 17%

304h ago

St. Simeon the Holy Fool

@simeonthefool.bsky.social

I expect we could all use a tiny little bit of good news right about now, so how about THEY JUST APPROVED A CURE FOR GODDAMN PANCREATIC CANCER HOLY FUCKING SHIT

194h ago

Debby Williams 💙♐️

@dwilliams1210.com

The Food and Drug Administration on Wednesday approved a groundbreaking new drug for advanced pancreatic cancer, offering U.S. patients a more effective treatment against one of the deadliest types of cancer.

147h ago

Ms B Moran1

So how is RFK Jr gonna screw THIS up?

JB1

I lost a dear friend to this awful disease. Seeing this approval makes me so happy. I just wish it was a few years sooner.

Sharon Carbine

@sharoncarbine.bsky.social

"FDA Approves Drug Poised to Transform Care for Pancreatic Cancer. In a key clinical trial, patients who got the pill, daraxonrasib, lived twice as long as those who got chemotherapy." GIFT: www.nytimes.com/2026/08/26/s...

146h ago

Ingvald

@ingvald1.bsky.social

F.D.A. Approves Drug Poised to Transform Care for Pancreatic Cancer You can read it for free without a subscription. www.nytimes.com/2026/08/26/s...

115h ago

Espy

@esp1371.bsky.social

My friend's sister died of pancreatic cancer just 4 months ago. I am thankful that these researchers have found something that will provide other families some hope.

244h ago

Robin M Goffena2

My father-in-law died in 2011 from it, too. Nasty & quick. What an incredible blessing that other people & families hopefully will be spared the worst in future.

Julia Carle1

I’ve lost two people close to me. Pancreatic cancer is the devil. This is such good news.

post malone ergo propter malone

@proptermalone.bsky.social

ok so wait though he made it five years with pancreatic cancer before this stuff?

224h ago

10/11 News

@1011now.com

FDA approves landmark pancreatic cancer drug that’s shown to improve survival

64h ago

Moist Owlet [24.15 Barleycorns] (Antibacterial)

@g-sharp-major.bsky.social

This is awesome. My dad has (had?) stage 4 pancreatic cancer, and he’s so kicking with similar results on olaparib. But that’s because he has the right BRCA mutations to make it work. A similar treatment that works for anyone/everyone is a f•cking miracle.

154h ago

Teddy Focaccia

@kmaustinyoung.bsky.social

My sister-in-law in Austin just started on this drug after being diagnosed with pancreatic cancer last November. They fortunately found it early, and she’s relatively young (early 50s) and otherwise healthy. But this drug is very hopeful.

136h ago

Sorry Buddy

@3cityyimby.bsky.social

For all the negative news, we still live in an age of miracles and wonders. I lost an uncle to pancreatic cancer, and I guess the only small mercy about it was it happened so quickly he didn't have time to suffer much.

94h ago

3 sources

bbc.co.ukFDA approves breakthrough drug daraxonrasib to treat pancreatic cancer apnews.comFDA approves landmark pancreatic cancer drug that's shown to improve survival theguardian.comFDA gives expedited approval to new groundbreaking pancreatic cancer drug

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FDA approves daraxonrasib for advanced pancreatic cancer

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