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Unreported death in Chinese gene‑editing trial revealed

scienceJul 23, 202619328

An investigation by Science and Retraction Watch revealed that a child died after receiving an experimental base-editor infusion in an n-of-1 gene‑editing trial in China that was never publicly reported. Parents paid roughly $860,000 for the treatment, which delivered trillions of viral particles carrying the base editor into the child’s spinal fluid. Seven days after the infusion the child died of a severe immune reaction linked to the therapy, and the family says they were not told about serious adverse findings in primate studies of the same editor. The researchers who later published related animal work in a high-profile journal omitted the family’s financial contribution and references to the treated child. Scientists quoted in the investigation called the outcome avoidable, and the family is now seeking accountability. The reporting raises questions about transparency, consent, and oversight in single-patient experimental gene therapies in China.

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